By Hooper N.M. (ed.)
This article brings jointly the most ideas of biochemistry, phone biology, and molecular biology which are getting used to enquire the molecular foundation of Alzheimer's affliction. It presents a precis of presently on hand healing brokers and customers for destiny medicinal drugs.
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Extra info for Alzheimer's Disease
The gene exists in two forms, depending on the presence of a G or A nucleotide at position 1450 resulting in a Ile/Ile, Ile/Val, or Val/Val genotype at residue 443. Val/Val homozygosity was significantly increased in cases compared with controls, although in a larger cohort Premkumar et al. (111) were unable to confirm this association in Caucasian patients. More recently, an association with a variant of α-2-macroglobulin was reported (112) although again this has not been confirmed in other patient populations (St.
A full length report of this study has not yet appeared. 2. 1. Cognitive Assessment Instruments At the present time, guidelines developed by an expert panel convened by the FDA in the late 1980s called for the use of an objective cognitive assessment and a clinician’s global assessment. The Alzheimer’s Disease Assessment Scale — cognitive portion (ADAS-cog) (12) rapidly became the standard tool for cognitive assessment of AD patients in clinical trials. The MMSE (6) is used as a secondary measure of outcome because it serves in another capacity, namely as the basis for one of the inclusion criteria.
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